Leonard Shelby is a man with a bizarre disorder: the inability to form new memories. Ever since the fateful night when his wife was murdered, anyone Leonard has met, or anything he has done, simply vanished from his mind. Who are his friends? Who are his enemies? What is the truth? The answers change from second to second as Leonard seeks vengeance for his wife's murder...and sinks into an abyss of uncertainty and danger.

Diego (Vadhir Derbezi), conoce a Luci (Ximena Romo), pero ella al día siguiente, no lo recuerda, debido a un accidente que sufrió años atrás provocanda que cada noche su memoria se borre. Diego hará cualquier cose para encontrar cada día la manera de enamorarla.